DNA Transcription (Advanced)

DNA Transcription (Advanced)|Biochemistry Center




DNA Transcription (Advanced)

Transcription is the process by which the information in DNA is copied into messenger RNA (mRNA) for protein production.
Originally created for DNA Interactive ( http://www.dnai.org ).
TRANSCRIPT: The Central Dogma of Molecular Biology: “DNA makes RNA makes protein” Here the process begins. Transcription factors assemble at a specific promoter region along the DNA. The length of DNA following the promoter is a gene and it contains the recipe for a protein. A mediator protein complex arrives carrying the enzyme RNA polymerase. It manoeuvres the RNA polymerase into place… inserting it with the help of other factors between the strands of the DNA double helix. The assembled collection of all these factors is referred to as the transcription initiation complex… and now it is ready to be activated. The initiation complex requires contact with activator proteins, which bind to specific sequences of DNA known as enhancer regions. These regions may be thousands of base pairs distant from the start of the gene. Contact between the activator proteins and the initiation-complex releases the copying mechanism. The RNA polymerase unzips a small portion of the DNA helix exposing the bases on each strand. Only one of the strands is copied. It acts as a template for the synthesis of an RNA molecule which is assembled one sub-unit at a time by matching the DNA letter code on the template strand. The sub-units can be seen here entering the enzyme through its intake hole and they are joined together to form the long messenger RNA chain snaking out of the top.

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40 thoughts on “DNA Transcription (Advanced)|Biochemistry Center”

  1. It’s not a “dogma”! A “dogma” is what religitard terrorists use, to stop people questioning their nonsense! This here very much questioned and answered! Which is the exact opposite of a dogma!

  2. Intelligent life came from nothing chance in billions of years process? Highly unlikely!! The probability of universe came into being by chance alone is like winning poker 100 times in a row! There is a mind behind this, God.

  3. Wow, the laws of nature, physics, chemistry, and lots of time. Thank you Darwin, for showing us how this can actually happen without a designer. If you only knew how right you were.

    And for those of you that prefer the designer explanation, please ask yourself what designed the designer, and that designer, and so on and so on. This is why intellectually honest people find this explanation terribly insufficient and weak. Get with it people, and remember that the amazing natural design depicted in this video is also loaded with imperfect design, and this imperfection serves to support evolution as much as anything else.

  4. It’s NOT a “dogma”! A dogma is blind belief without checking. Which is the exact opposite of the scientific model!
    Why can’t Americans even do science, without poisoning it with the religitard mental illness?

  5. So I've recently read abt this 5' exonuclease called rat1 (Xrn2 in humans) tht is involved in transcriptional termination and does this by degrading the RNA pol. My gripe wth this is tht this exonuclease has to degrade the nascent RNA to intercept the RNA pol frm the 5' end. Can someone pls clarify this? Bc frm what I understand, the RNA will need to be made again frm scratch, which does not make sense as it defeats the point of transcription. Sorry tldr.

  6. Is DNA only read and proteins made during mitosis or is DNA constantly being unzipped and rejoined at specific points along the molecule to make specific proteins when needed even when the cell isn't dividing?    Are there molecules that can read the DNA sequence through the major/minor grooves of the molecule even before the DNA is unzipped?

  7. Question about the 'unzipping' part of transcription:
    My biology teacher told me that DNA helicase does this,
    however my Chemistry teacher told me that RNA polymerase does this and helicase is only involved in replication.
    Who is correct? :'( they're both great teachers.

    EDIT: after a lot of googling it seems pretty much 50/50 to either helicase or polymerase – if anyone knows which one it actually is please let me know how you know lol and why lots of people are mistaken.
    Any info would be really appreciated!

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