Glycolysis Pathway Made Simple !! Biochemistry Lecture on Glycolysis
Glycolysis Pathway Made Simple !! Biochemistry Lecture on Glycolysis
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Glycolysis Pathway Made Simple! Biochemistry Lecture on Glycolysis
Glycolysis (from glycose, an older term[1] for glucose + -lysis degradation) is the metabolic pathway that converts glucose C6H12O6, into pyruvate, CH3COCOO− + H+. The free energy released in this process is used to form the high-energy molecules ATP (adenosine triphosphate) and NADH (reduced nicotinamide adenine dinucleotide).
Glycolysis is a determined sequence of ten enzyme-catalyzed reactions. The intermediates provide entry points to glycolysis. For example, most monosaccharides, such as fructose and galactose, can be converted to one of these intermediates. The intermediates may also be directly useful. For example, the intermediate dihydroxyacetone phosphate (DHAP) is a source of the glycerol that combines with fatty acids to form fat.
Glycolysis is an oxygen independent metabolic pathway, meaning that it does not use molecular oxygen (i.e. atmospheric oxygen) for any of its reactions. However the products of glycolysis (pyruvate and NADH + H+) are sometimes metabolized using atmospheric oxygen.[4] When molecular oxygen is used for the metabolism of the products of glycolysis the process is usually referred to as aerobic, whereas if no oxygen is used the process is said to be anaerobic.[5] Thus, glycolysis occurs, with variations, in nearly all organisms, both aerobic and anaerobic. The wide occurrence of glycolysis indicates that it is one of the most ancient metabolic pathways.[6] Indeed, the reactions that constitute glycolysis and its parallel pathway, the pentose phosphate pathway, occur metal-catalyzed under the oxygen-free conditions of the Archean oceans, also in the absence of enzymes. Glycolysis could thus have originated from chemical constraints of the prebiotic world.
Glycolysis occurs in most organisms in the cytosol of the cell. The most common type of glycolysis is the Embden–Meyerhof–Parnas (EMP pathway), which was discovered by Gustav Embden, Otto Meyerhof, and Jakub Karol Parnas. Glycolysis also refers to other pathways, such as the Entner–Doudoroff pathway and various heterofermentative and homofermentative pathways. However, the discussion here will be limited to the Embden–Meyerhof–Parnas pathway.
Preparatory phase
The first five steps are regarded as the preparatory (or investment) phase, since they consume energy to convert the glucose into two three-carbon sugar phosphates
Pay-off phase
The second half of glycolysis is known as the pay-off phase, characterised by a net gain of the energy-rich molecules ATP and NADH. Since glucose leads to two triose sugars in the preparatory phase, each reaction in the pay-off phase occurs twice per glucose molecule. This yields 2 NADH molecules and 4 ATP molecules, leading to a net gain of 2 NADH molecules and 2 ATP molecules from the glycolytic pathway per glucose.
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Youe videos are so much simplified….very helpful for nursing students like me
TCA cycle was also awesome…love the way you explain each and every part.
sorry 2 ATPs are not used they are released. check 6:00 time video
Are you Indian?
This is by far the best video I have seen on glycolysis , I literally fell in love with the glycolysis pathway on the spot.
Which device u r using to make videos?
Simple … cute… i was struggling to memorise it … but u maid it lightly sir … thank you so much
You made this topic soo easy to be understood…thank u so much sir.
The best explanation so far of glycolysis ☺️👍🏻💋
Best video ever made on glycolysis… really helpful, thanking you 😍😍
Really helpful! Thank you
Thanks sir
Thank you!
Thank you so much for this video!!! I'm learning this process for my Biology 1 course and your explanation was extremely helpful 🙂
Thank you 😭😭😭😭♥️♥️♥️♥️👍🏼
Great video
I was struggling with following all the steps on my professor’s slides…this cleared it up for me so much. Thank you!!
👍👏👏👏😉 Thank you!
One of the best video ever for glycolysis!!!!!Thank you sooo much sirrjiiii:-)
Raj from the big bang theory is that you?
Thank you!!!
Thanku so much it is really helpfull for me thanku🙏
Has anyone stopped to consider how the enzymes that enable all these reactions in sequence could have come about by supposed natural process? What's the chance of that?
idk who this indian guy is but hes needs a flippin raise can i get a "FAX" in the chat?
I think I want to marry you after watching this. Allah cannot bless you enough.
Thank you , you explain it clearly
Thank you so much, you made it as clear as crystal 🥺💕💕
Love you sir thanku 🙏🙏🙏
You are awesome
Brilliant video! Helped me alot 🙂
❤❤Lovely video
Thanks
تاج راسي والله
Osm, very good keep it up and thankyou
Thank you, summed up very well
Best video of the 5 I've watched today trying to understand this. The most linear presentation I've seen. Thank you so much you are awesome and super duper smart thank a lot
You deserve more than a simple thank
Best video I had ever seen
Glt hai bhai kuch
Thankew for the video ❤️
Thank you Soo much !!! This made it Soo clear 😭
thank youuu kekeke